Funded by the National Institutes of Health (NIH), the Access for ALL in ALS Consortium (ALL ALS), is a community of two coordination centers and 35 research sites across the United States, conducting a combined longitudinal natural history study and biomarker collection study for ALS.
ALL ALS research engages with people currently living with ALS, potential ALS gene carriers, and family members, friends, and community partners to better understand all stages of ALS disease progression.
* The number of vials collected per visit and sample volumes are dependent on sample type and can vary between visits. Not all participants are providing CSF samples.
The ALL ALS PREVENT study focuses on understanding the earliest stages of the disease in people at risk, while the ASSESS ALL ALS study collects vital data on individuals living with ALS to track disease progression and identify new biomarkers.
The Accelerating Access to Critical Therapies for ALS Act (ACT for ALS), which was signed into law in the United States on December 23, 2021, established an HHS, public-private partnership (PPP) for rare neurodegenerative diseases. One component of this PPP is an Accelerating Medicines Partnership® for ALS (AMP® ALS).The ALL ALS Consortium was created as part of this initiative to move forward ALS research.
Funded by the NIH/NINDS, the Access for ALL in ALS Consortium (ALL ALS), is a community of two coordination centers and 34 research sites across the United States, conducting a combined longitudinal natural history study and biomarker collection study for ALS. This study will include both people currently living with ALS, and asymptomatic ALS gene carriers.
Stay informed about the latest breakthroughs and developments in ALS research by exploring our press releases and news section.
ALL ALS Consortium Launches Website to Advance ALS Research
The Access for All in ALS (ALL ALS) Consortium announced the launch of its official website, creating a central hub for information about its initiatives and clinical research studies. ALL-ALS.org is designed to inform and engage researchers, clinicians, and current and prospective study participants.
Recent progress in therapeutics for amyotrophic lateral sclerosis (ALS) has spurred development and imbued the field of ALS with hope for more breakthroughs, yet substantial scientific gaps persist. This unmet need remains a stark reminder that innovative paradigms are needed to invigorate ALS research. To move toward more informative, targeted, and personalized drug development, the National Institutes of Health (NIH) established a national ALS clinical research consortium called Access for ALL in ALS (ALL ALS).
The Access for All in ALS Consortium (ALL ALS) announced the successful enrollment of the first participant.
Established in the autumn of 2023 with funding from the National Institutes of Health (NIH), ALL ALS is a multi-institutional effort, and aims to disrupt the ALS clinical research landscape using open science methods to build broadly accessible resources to advance ALS research. The consortium brings together research scientists from across the country, combining their efforts to collect clinical and biomarker data from people with ALS symptoms, asymptomatic individuals at risk of developing inherited forms of ALS, and control participants. The ALL ALS clinical and genomic data and biofluid collections will help researchers investigate the antecedents of ALS, its onset, progression, prognostication, and response to effective therapies.
ALS is a complex neurodegenerative disease, but the causes remain poorly understood and there are few effective therapies available. There is an urgent need for large-scale, collaborative efforts to identify useful biofluid biomarkers that can guide researchers about its onset, progression, and response to effective therapies.
To achieve these goals, the NIH has established a transformative national ALS clinical research consortium called Access for All in ALS (ALL ALS). This new consortium is a multi-institutional effort and aims to disrupt the ALS clinical research landscape in the U.S. It will operationalize recommendations of the Accelerating Access to Critical Therapies for ALS Act (ACT for ALS) Public Private Partnership. This grant is made possible by the Accelerating Access to Critical Therapies for ALS Act, which was signed into law in December 2021.
The ALL ALS Consortium and all related studies are funded by the National Institutes of Health (NIH), Grant # 1OT2NS136938 and 1OT2NS136939.