About ALL ALS

Advancing the future of ALS research

Working Together to Find
an ALS Cure

The ALL ALS Clinical Research Consortium is a community of researchers working closely with people affected by ALS, government, industry, and non-profit organizations to find a cure for this devastating disease. Funded by the NIH, this collaborative research effort is collecting a broad array of clinical data and biospecimens from thousands of participants living with ALS, at genetic risk for ALS, or healthy controls​ from across the US to advance ALS research that will lead to longer, better lives.

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Doctor and medical professionals reviewing data over a tablet

The Future of ALS Research:

ALL ALS is a proud contributor to the Accelerating Medicines Partnership® for ALS (AMP® ALS). AMP ALS is an essential component of the public-private partnership called for in Public Law 117-79 -Accelerating Access to Critical Therapies for ALS Act (ACT for ALS). AMP ALS is bringing together data and biospecimens from many different studies and facilitating broad use to improve diagnosis and develop effective therapies for ALS​. This collaboration represents a significant step forward in ALS research, uniting government, industry, and non-profit organizations in the fight against this disease.

Our Goals

Create a large database for ALS research

  1. We include participants from across the country at all stages of disease progression (i.e., at risk, early disease, late disease) as well as control participants

Collect clinical information, biofluids, and patient-reported outcomes (PROS)

  1. Collect longitudinal blood and cerebrospinal fluid (CSF) samples to build a large biofluid repository for future research
  2. Relate new clinical and digital outcome measures to current trial measures
  3. Integrate patient-reported outcomes (PROS) with established trial measures

Develop knowledge through collaborative networks.

  1. Establish clinical research infrastructure that can be leveraged for future clinical trials
  2. Collect data and biofluids that will contribute to AMP ALS collaboration

Promote transparency & accessibility in knowledge sharing among researchers

  1. Empower collaboration to accelerate future scientific breakthroughs
  2. Data will be made available upon request for future research

Advance ALS drug development with new breakthroughs

  1. Fill gaps from other clinical studies to lead to more efficient clinical trials
  2. Improve our understanding of disease pathways and identify targets for treatment
  3. Improve diagnosis and prevention strategies that could lead to longer and better lives

Join us in the fight against ALS!

We are actively seeking participants for our ongoing studies. Visit our studies page to learn more about eligibility criteria and how to get involved. Together, we can make a difference!

Participate
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Collaborators

We know we are not alone in our efforts to understand and fight ALS.  We are working to partner with many organizations and research groups to expand this network of impact! The following organizations are some of our partners in this work:

CDC Logo

CDC

The National ALS Registry is seeking to find the causes and risk factors for ALS. Please consider joining the Registry and help researchers find answers. www.cdc.gov/als

TARGET ALS Logo

TARGET ALS

Target ALS is a medical research foundation dedicated to breaking down barriers in Amyotrophic Lateral Sclerosis (ALS) research to find effective treatments. Since its inception, Target ALS has supported the most promising ideas in fundamental scientific research, with the goal of developing treatments that allow individuals with ALS to live long, high-quality lives.

FNIH Logo

FNIH

Clinic-Based Multi-Site ALS Natural History & Biofluid Study Logo

Natural History Study

Community Partners

Our community partners help strengthen awareness of and participation in ALL ALS across the ALS community. The following organizations extend the reach of our mission and support all those impacted by ALS:

ALS New Mexico

ALS United Connecticut

I AM ALS

Your ALS Guide

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Her ALS Story

Join the fight against ALS!

Your expertise can make a real difference. The Accelerating Medicines Partnership® for Amyotrophic Lateral Sclerosis (AMP® ALS) is seeking individuals with lived experience of ALS. Whether you’re diagnosed, at genetic risk, a caregiver, or a family member, your insights are invaluable.

Get involved today:
  • Shape groundbreaking ALS research initiatives
  • Ensure the patient perspective is heard
  • Help accelerate the discovery of effective treatments

Take action now:

If you are interested in joining the Lived Experience and Advocacy Working Group, visit the PWLE Involvement and ALS Advocacy Community section of the AMP® ALS website or email nihalsinformation@ninds.nih.gov.

I’m interested in the AMP® ALS Lived Experience and Advocacy Working Group

Please reach out if you would like to collaborate!

Contact Us!

ALL ALS Consortium

If you wish for a member of study team to contact you about the ALL ALS consortium, please fill out our Participant Interest Intake Form.

Get More Information

Funding:

The ALL ALS Consortium and all related studies are funded by the National Institutes of Health (NIH), Grant # 1OT2NS136938 and 1OT2NS136939.

Participant Interest Form